• 2024年
• 2023年

石川 吉伸; 免疫チェックポイント低分子阻害剤のインシリコ創薬の事例, PHARM STAGE, 20, 20-25 (2020)

石川 吉伸（分担）; インシリコを活用した化合物の安定分子構造生成と結合親和性の予測、『in silico創薬におけるスクリーニングの高速化・高精度化技術』、技術情報協会（2018）

秋山 靖人, 芦澤 忠, 飯塚 明, 井上 謙吾, 安藤 隆幸, 石川 吉伸
特願2021-045476　PD-1及び／又はPD-L1の阻害剤

藤村 篤史, 井上 謙吾, 安藤 隆幸, 石川 吉伸, 富澤 一仁

特願2019-153832 ＲＮＡメチルトランスフェラーゼ阻害剤及びそのスクリーニング方法

山口 健, 楠原 正俊, 芹澤 昌邦, 望月 徹, 大島 啓一, 畠山 慶一, 浦上 研一, 大浪 俊平, 秋山 靖人, 丸山 宏ニ, 井上 謙吾, 下田 勇治, 長嶋 剛史, 石川 吉伸

PCT/JP2017/028315 がんの発症リスクの有無を判定する方法

益谷 美都子, 佐久間 浩彰, 佐々木 由香, 小泉 史明, 小寺 康夫, 佐々木 貴之, 下山 達, 井上 謙吾, 松野 研司, 大川原 正, イスラム ラフィクル, 高村 岳樹, 入江 徹美, 石川 吉伸

PCT/JP2016/004733 新規抗がん薬

Koichi Kato, Tomoki Nakayoshi, Yasuro Shinohara, Eiji Kurimoto, Akifumi Oda, Yoshinobu Ishikawa, Theoretical Studies on the Reaction Mechanism of Schiff Base Formation from Hexoses, The Journal of Physical Chemistry B, 128, 4952–4958, 2024

Koichi Kato, Tomoki Nakayoshi, Sho Hioki, Masahiro Hiratsuka, Yoshinobu Ishikawa, Eiji Kurimoto, Akifumi Oda, Structural Impact Assessment of Cytochrome P450 2A13 Polymorphisms Using Molecular Dynamics Simulations, Biological & Pharmaceutical Bulletin 47, 620-628, 2024

Koichi Kato, Tomoki Nakayoshi, Yuki Kitamura, Eiji Kurimoto, Akifumi Oda, Yoshinobu Ishikawa, Identification of the Most Impactful Asparagine Residues for γS-Crystallin Aggregation by Deamidation, Biochemistry, 62, 1679-1688, 2023

Koichi Kato, Tomoki Nakayoshi, Yuki Kitamura, Eiji Kurimoto, Akifumi Oda, Yoshinobu Ishikawa、Identification of the Most Impactful Asparagine Residues for γS-Crystallin Aggregation by Deamidation, Biochemistry, 62, 1679-1688 (2023)

Nurbyek S, Buyankhishig B, Suganuma K, Ishikawa Y, Kutsuma M, Abe M, Sasaki K, Davaapurev BO, Batkhuu J, Murata T. Phytochemical investigation of Scutellaria scordiifolia and its trypanocidal activity, Phytochemistry, 209, 113615 (2023)

Akiyama Y, Ashizawa T, Iizuka A, Ando T, Ishikawa Y, Kondou R, Miyata H, Maeda C, Kanematsu A, Sugino T, Yamaguchi K. Development of novel small molecules with PD-1/PD-L1 binding inhibition and potent antitumor effects in humanized mouse, Anticancer Resarch, 42, 5233-5247 (2022)

Yokoyama H, Kamei N, Konishi K, Hara K, Ishikawa Y, Matsui I, Forterre P, Hashimoto H
Structural basis for peptide recognition by archaeal oligopeptide permease A

PROTEINS,90, 1434-1442 (2022)

Kato K, Shinohara Y, Nakayoshi T, Kurimoto E, Oda A, Ishikawa Y.
Computational quantitation of the aldehyde forms of aldohexoses and disaccharides composed of d-glucose: predictions of their reactivities in the Maillard reaction

Comput. Theor. Chem., 1209, 113605 (2022)

Munsimbwe L, Suganuma K, Ishikawa Y, Choongo K, Kikuchi T, Shirakura I, Murata T.
Benzophenone glucosides and B-type proanthocyanidins dimer from Zambian Cassia abbreviata and their trypanocidal activities

J. Nat. Prod., 85, 91-104 (2022)

Asai H, Kato K, Nakayoshi T, Ishikawa Y, Kurimoto E, Oda A, Fukuishi N.
Acceleration of nonenzymatic glutamine deamidation by a C-terminal adjacent glycine residue: A computational mechanistic study

AppliedChem, 1, 142-155 (2021)

Kato K, Nakayoshi T, Ishikawa Y, Kurimoto E, Oda A
Computational analysis of the mechanism of nonenzymatic peptide bond cleavage at the C-terminal side of an asparagine residue
ACS Omega, 6, 30078-30084 (2021)

Kato K, Nakayoshi T, Nokura R, Hosono H, Hiratsuka M, Ishikawa Y, Kurimoto E, Oda A

Deciphering Structural Alterations Associated with Activity Reductions of Genetic Polymorphisms in Cytochrome P450 2A6 Using Molecular Dynamics Simulations

Int. J. Mol. Sci., 22, 10119 (2021)

Yokoyama H, Kamei N, Konishi K, Hara K, Ishikawa Y, Matsui I, Forterre P, Hashimoto H

Preparation, crystallization, and X-ray analysis of archaeal oligopeptide permease A

Crystallography Reports, 66, 1298-1303 (2021)

Nasako H, Takashina Y, Eguchi H, Ito A, Ishikawa Y, Matsunaga T, Endo S, Ikari A.

Increase in toxicity of anticancer drugs by PMTPV, a claudin-1-binding peptide, mediated via down-regulation of claudin-1 in human lung adenocarcinoma A549 cells

Int. J. Mol. Sci., 21, 5909 (2020)

Derayea SM,Tsujino H, Oyama Y, Ishikawa Y, Yamashita T,Uno T.

Impact of single nucleotide polymorphisms (R132Q and W120R) on the binding affinity and metabolic activity of CYP2C19 toward some therapeutically important substrates

Xenobiotica, 50, 1510-1519 (2020)

Nurbek S; Murata T; Suganuma K; Ishikawa Y; Buyankhishig B; Kikuchi T; Byambajav T; Davaapurev B; Sasaki K; Batkhuu J.

Isolation and evaluation of trypanocidal activity of sesquiterpenoids, flavonoids, and lignans in Artemisia sieversiana collected in Mongolia

J. Nat. Med. 74, 750–757, (2020)

Murakami H, Asakawa T, Muramatsu Y, Ishikawa R, Hiza A, Tsukaguchi Y, Tokumaru Y, Egi M, Inai M, Ouchi H, Yoshimura F, Taniguchi T, Ishikawa Y, Kondo M, Kan T.

ITotal Synthesis of Sophoraflavanone H and Confirmation of Its Absolute Configuration

Org. Lett., 22, 3820-3824 (2020)

Nasako H, Akizuki R, Takashina Y, Ishikawa Y, Shinoda T, Shirouzu M, Asai T, Matsunaga T, Endo S, Ikari A

Claudin-2 binding peptides, VPDSM and DSMKF, down-regulate claudin-2 expression and anticancer resistance in human lung adenocarcinoma A549 cells

BBA-MOL CELL RES, 1867, 118642 (2020)

Hara K, Iida N, Tamafune R, Ohashi E, Sakurai H, Ishikawa Y, Hishiki A, Hashimoto H.

Structure of the RAD9-RAD1-HUS1 checkpoint clamp bound to RHINO sheds light on the other side of the DNA clamp

J. Biol. Chem., 295, 899-904 (2020)

Ashizawa T, Iizuka A, Tanaka E, Kondou R, Miyata H, Maeda C,Sugino T, Yamaguchi K, Ando T, Ishikawa Y, Ito M, Akiyama Y.

Antitumor activity of the PD-1/PD-L1 binding inhibitor BMS-202 in the humanized MHC-double knockout NOG mouse

Biomed. Res., 40, 243-250 (2019)

Murata T, Katagiri T, Ishikawa Y, Abe M, Takahashi E, Iwahana R, Sakamoto Y, Sasaki K.

Inhibitory Effects of Phenylpropanoid Derivatives from Oenanthe javanica on Antigen-stimulated Degranulation in RBL-2H3 Cells

J. Nat. Prod., 82, 1518-1526 (2019)

Odonbayar B, Murata T, Suganuma K, Ishikawa Y, Buyankhishig B, Batkhuu J, Sasaki K.

Acylated Lignans Isolated from Brachanthemum gobicum and Their Trypanocidal Activity

J. Nat. Prod., 82, 774-784 (2019)

Miyata R, Sahlan M, Ishikawa Y, Hashimoto H, Honda S, Kumazawa S.

Propolis components from stingless bees collected on South Sulawesi, Indonesia, and their xanthine oxidase inhibitory activity

J. Nat. Prod., 82, 205-210 (2019)

Nagasaka Y, Asakawa T, Shintaku S, Masuda A, Matsumura K, Inai M, Ishikawa Y, Egi M, Hamashima Y, Kan T.

Concise Synthesis of TAN1251C

Heterocycles, 99, 1095-1116 (2019)

Derayea SM, Tsujino H, Oyama Y,Ishikawa Y, Yamashita T, Uno T.

Investigation on drug-binding in heme pocket of CYP2C19 with UV-visible and resonance Raman spectroscopies

Spectrochim. Acta A, 209, 209-216 (2019)

Yokoyama H, Sawada J, Sato K, Ogo N, Kamei N, Ishikawa Y, Hara K, Asai A, Hashimoto H.

Structural and Thermodynamic Basis of the Enhanced Interaction between Kinesin Spindle Protein Eg5 and STLC-type Inhibitors

ACS Omega, 3, 12284-12294 (2018)

Hara K, Uchida M, Tagata R, Yokoyama H, Ishikawa Y, Hishiki H, Hashimoto H.

Structure of PCNA bound to APIM peptide reveals universality of PCNA interaction

Acta Cryst. F74, 214-221 (2018)

Hara K, Taharazako S, Ikeda M, Fujita H, Mikami Y, Kikuchi S, Hishiki A, Yokoyama H, Ishikawa Y, Kanno S, Tanaka K, Hashimoto H.

Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment maintaining phosphoprotein (CAMP)

J. Biol. Chem. 292, 17658-17667 (2017)

Konishi H, Matsubara M, Mori K, Tokiwa T, Arulmozhiraja S, Yamamoto Y, Ishikawa Y, Hashimoto H, Shigeta Y, Tokiwa H, Manabe K.

Mechanistic Insight into Weak-Base-Catalyzed Generation of Carbon Monoxide from Phenyl Formate and Its Application to Catalytic Carbonylation at Room Temperature without Use of External Carbon Monoxide Gas

Adv. Synth. Catal., 359, 3592-3601 (2017)

Nagasaka Y, Shintaku S, Matsumura K, Masuda A, Asakawa T, Inai M, Egi M, Hamashima Y, Ishikawa Y, Kan T.

Total Synthesis of TAN1251C via Diastereoselective Construction of the Azaspiro Skeleton

Org. Lett., 19, 3839-3842 (2017)