薬学部
教員紹介
![[写真]](/images/shared/teacher/pht_teacher505_s.jpg)
| 氏名 | 栗原 正明 |
|---|---|
| フリガナ（ローマ字） | クリハラ マサアキ（Masaaki Kurihara） |
| 職名 | 教授 |
| 学位 | 薬学博士 |
| 担当授業科目 | 化学系実習、有機化学系実習、有機化学Ⅲ、創薬化学 |
| 専門分野 | 有機化学、有機合成化学、創薬化学、計算機化学 |
| 現在の研究テーマ | 創薬を志向した分子の設計と機能化 |
| 研究内容キーワード | ドッキングスタディ、ドラッグデザイン、核内受容体、プロテインノックダウン分子 |
| 研究室紹介 | 薬化学 |
| ティーチング・ ポートフォリオ |
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| 主な著書・学術論文 | Ichimaru Y, Kurihara M, Fujita M, Otsuka M, Kurosaki H, et al: Design, synthesis and characterization of 1-(anthracen-9-ylmethyl)-1,5,9-triazacyclododecane (Ant-[12]aneN3) and its DNA photocleavage activity,Chem Pharm Bull. 2025;73(2):103-107. |
| Arai Y, Yuyama M, Sato T, Kurihara M: Prediction of fentanyl derivative in silico bioactivity using a quantitative structure-activity relationship model, Journal of the International University of Health and Welfare, 2, 2024, 102-109. | |
| Moriya S, Kurihara M, Kittaka A, Sugiyama T, et al: Synthesis and properties of PNA containing a dicationic nucleobase based on N4-benzoylated cytosine, Bioorg Med Chem Lett. 2023 May 15;88:129287 | |
| Y. Ichimaru, M. Kurihara, M, Fujita, M. Otsuka, H. Kurosaki et al: Structural Characterization of Zinc(II)/Cobalt(II) Complexes of Chiral N-(Anthracen-9-yl)methyl-N,N-bis(2-picolyl)amine and Evaluation of DNA Photocleavage Activity, Chem Pharm Bull., 2023, 71(7), 545-551. | |
| Yuyama M, Kurihara M, et al:Design and synthesis of novel estrogen receptor antagonists with acetal containing biphenylmethane skeleton, Results in Chemistry, 3, 2021, 100124 | |
| Moriya S, Kurihara M, Sugiyama T et al: Synthesis and characterization of PNA oligomers containing preQ1 as a positively charged guanine analogue, Bioorg Med Chem Lett. 2021, 39, 127850 | |
| Yuyama M, Kurihara M, et al: Risk prediction method for anticholinergic action using auto-quantitative structure activity relationship and docking study with molecular operating environment, Chem Pharm Bull, 2020, 68(8), 773-778 | |
| Shoda T, Kurihara M, et al: Targeted protein degradation by chimeric compounds using hydrophobic E3 ligands and adamantane moiety, Pharmaceuticals (Basel). 2020;13(3):34 | |
| Ohoka N, Kurihara M, Naito M, et al:Development of small molecule chimeras that recruit AhR E3 ligase to target proteins, ACS Chem Biol. 2019, 14, 2822-2832. | |
| Misawa T, Kurihara M, Demizu Y, et al: Structural development of non-secosteroidal vitamin D receptor (VDR) ligands without any asymmetric carbon, Bioorg Med Chem. 2018, 26, 6146-6152. | |
| Okitsu K, Kurihara M, Demizu Y, et al: Development of a small hybrid molecule that mediates degradation of His-tag fused proteins, J Med Chem. 2018, 61, 576-582. | |
| Tsuji G, Kurihara M, Shoda T, et al: Design and synthesis of cell-permeable fluorescent nitrilotriacetic acid derivatives, Bioorg Med Chem. 2018, 26, 5494-5498. | |
| Shoda T, Kurihara M, et al: Tamoxifen and fulvestrant hybrids showed potency as selective estrogen receptor down-regulators, Med Chem. 2017;13(3):206-213. | |
| Eto R, Kurihara M, Tanaka M, et al:Diastereomeric right- and left-handed helical structures with fourteen (R)-chiral centers, Chemistry. 2017, 23, 18120-18124. | |
| Sugiyama T, Kurihara M, Kittaka A, et al: PNA monomers fully compatible with standard Fmoc-based solid-phase synthesis of pseudocomplementary PNA, Bioorg Med Chem Lett. 2017, 27, 3337-3341. |