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学部・学科・専攻

教員紹介(薬学部 医療薬学科)

[写真]

コロナ禍において、若者の“いま”は犠牲とされてしまいました。その裏側で、皆さんの未来を守るために多くの医療人が身を削っていました。そしていくつかの薬剤が、新型コロナウイルス感染症の治療に役立っていました。たとえ未知の疾患であっても薬のスペシャリストである薬剤師なら、病態と薬の作用メカニズムを基に薬剤の有効性を推定し、その治療に貢献できます。次世代の未来を守る一員として、医療人を目指しませんか。

氏名 加藤紘一
フリガナ(ローマ字) カトウ コウイチ(Koichi Kato)
職名 講師
学位 博士(薬学)
担当授業科目 分析化学II,III
専門分野 生物物理学、計算科学、
現在の研究テーマ タンパク質構造およびタンパク質間相互作用に関する研究、タンパク質の非酵素的翻訳後修飾に関する研究
研究内容キーワード タンパク質間相互作用、非酵素的翻訳後修飾、分子動力学シミュレーション、量子化学計算、タンパク質工学
主な著書・学術論文 Aqua(1,4,7,10-tetraazacyclododecane)zinc(II)bis(perchlorate) Yoshimi Ichimaru, Koichi Kato, Hiromasa Kurosaki, Haruto Fujioka, Misa Sakai, Yoshihiro Yamaguchi, Jin Wanchun, Kirara Sugiura, Masanori Imaia, Tohru Koike. IUCrData 6, x2103997, 2021
DNA-cleavage activity of the iron(II) complex with optically active ligands, meta- and para-xylyl-linked N',N'-dipyridylmethyl-cyclohexane-1,2-diamine. Koichi Kato,Yoshimi Ichimaru,Yoshinori Okuno,Yoshihiro Yamaguchi,Wanchun Jin,Mikako Fujita,Masami Otsuka,Masanori Imai,Hiromasa Kurosaki. Bioorganic & medicinal chemistry letters 36, 127834-127834, 2021
Modification of the pH Dependence of Assembly of Yeast Cargo Receptor Emp47p Coiled-Coil Domains: Computational Design and Experimental Mutagenesis. Koichi Kato,Tomoki Nakayoshi, Eiji Kurimoto, Akifumi Oda. The journal of physical chemistry. B 125, 2222-2230, 2021
Design and synthesis of an anthranyl bridged optically active dinuclear iron(II)-ligand and evaluation of DNA-cleaving activity. Yoshimi Ichimaru, Koichi Kato, Yoshinori Okuno, Yoshihiro Yamaguchi, Wanchun Jin, Mikako Fujita, Masami Otsuka, Masanori Imai, Hiromasa Kurosaki. Bioorganic & medicinal chemistry letters 35, 127782-127782, 2021
Molecular Mechanisms of Succinimide Formation from Aspartic Acid Residues Catalyzed by Two Water Molecules in the Aqueous Phase. Tomoki Nakayoshi, Koichi Kato, Shuichi Fukuyoshi, Ohgi Takahashi, Eiji Kurimoto, Akifumi Oda. International journal of molecular sciences. 22, 509, 2021
Crystal Structure of [11,14,17,110,51,54,57,510-Octaaza-1,5(1,4)-dicyclododecana-3,7(1,3)-dibenzenacyclooctaphane]zinc(II) tetrakis(nitrate), [m,m-bis(ZnII-cyclen)](NO3)4 Yoshimi ICHIMARU, Wanchun JIN, Yoshihiro YAMAGUCHI, Kirara SUGIURA, Masanori IMAI, Hiromasa KUROSAKI, Haruto FUJIOKA, Tohru KOIKE, Yuhzo HIEDA, Koichi KATO. X-ray Structure Analysis Online 37, 15-16, 2020
Influence of the conformations of αA-crystallin peptides on the isomerization rates of aspartic acid residues. Tomoki Nakayoshi, Koichi Kato, Eiji Kurimoto, Akifumi Oda. Biochimica et biophysica acta. Proteins and proteomics 1868, 140480-140480, 2020
Mechanisms of Deamidation of Asparagine Residues and Effects of Main-Chain Conformation on Activation Energy. Koichi Kato, Tomoki Nakayoshi, Eiji Kurimoto, Akifumi Oda. International journal of molecular sciences 21, 7035, 2020
Computational studies on nonenzymatic succinimide-formation mechanisms of the aspartic acid residues catalyzed by two water molecules. Tomoki Nakayoshi, Koichi Kato, Shuichi Fukuyoshi, Hiro Takahashi, Ohgi Takahashi, Eiji Kurimoto, Akifumi Oda. Biochimica et biophysica acta. Proteins and proteomics 1868, 140459-140459, 2020
Analysis of the susceptibility of reducing disaccharides composed of d-glucose to glycation using the Maillard reaction and a novel sensitive method that measures the percentage of the open-ring form. Yasuro Shinohara, Yurika Ozawa, Akimi Okita, Koichi Kato, Taku Chiba, Nobuaki Miura, Jun-Ichi Furukawa. Carbohydrate research 493, 108019, 2020
Molecular Dynamics Simulations for Three-Dimensional Structures of Orotate Phosphoribosyltransferases Constructed from a Simplified Amino Acid Set. Koichi Kato, Tomoki Nakayoshi, Mizuha Sato, Eiji Kurimoto, Akifumi Oda. ACS omega 5, 13069-13076, 2020
Computational Studies on the Mechanisms of Nonenzymatic Intramolecular Cyclization of the Glutamine Residues Located at N-Termini Catalyzed by Inorganic Phosphate Species. Tomoki Nakayoshi, Koichi Kato, Eiji Kurimoto, Akifumi Oda. ACS omega 5, 9162-9170, 2020
Development of Force Field Parameters for p-Carborane to Investigate the Structural Influence of Carborane Derivatives on Drug Targets by Complex Formation. Koichi Kato, Tomoki Nakayoshi, Hiroki Inoue, Shuichi Fukuyoshi, Kiminori Ohta, Yasuyuki Endo, Eiji Kurimoto, Akifumi Oda. Biological & pharmaceutical bulletin 43, 1931-1939, 2020
Activation of Ligand Reaction on an Iron Complex: H/D Exchange Reaction of a Low-Spin Bis[2-(Pyridylmethylidene)-1-(2-pyridyl)methylamine]iron(II) Complex. Masanori Imai, Koichi Kato, Yoshihiro Yamaguchi, Mikako Fujita, Masami Otsuka, Hiromasa Kurosaki. Chemical & pharmaceutical bulletin 68, 713-716, 2020
Crystal Structure of [3-(1,4,7,10-Tetraazacyclododecan-1-yl)propan-1-amine]zinc(II) Bis(perchlorate), [ZnIL](ClO4)2. ICHIMARU Yoshimi, IMAI Masanori, FUJIOKA Haruto, HIEDA Yuhzo, KOIKE Tohru, KUROSAKI Hiromasa, KATO Koichi. X-Ray Structure Analysis Online (Web) 36, 43-44, 2020
Crystal Structure of 5-Methoxyindirubin 3-Oxime. NAKAMURA Niina, ICHIMARU Yoshimi, ICHIMARU Yoshimi, KATO Koichi, SANO Makoto, KUROSAKI Hiromasa, HAYASHI Kazuhiko, MIYAIRI Shinichi. X-Ray Structure Analysis Online (Web) 36, 47-48, 2020
ER subtype selectivity of m-carborane-containing phenols: C-alkyl groups on the m-carborane cage enhance ERα selectivity. Kiminori Ohta, Takumi Ogawa, Koichi Kato, Akifumi Oda, Yasuyuki Endo. Bioorganic & medicinal chemistry letters 29, 2290-2293, 2019
Three dimensional structures of putative, primitive proteins to investigate the origin of homochirality. Akifumi Oda, Tomoki Nakayoshi, Koichi Kato, Shuichi Fukuyoshi, Eiji Kurimoto. Scientific reports 9, 11594, 2019
Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues. Yukihiro Yoshida, Hidetsugu Fujigaki, Koichi Kato, Kyoka Yamazaki, Suwako Fujigaki, Kazuo Kunisawa, Yasuko Yamamoto, Akihiro Mouri, Akifumi Oda, Toshitaka Nabeshima, Kuniaki Saito. Scientific reports 9, 10243, 2019
Computational Studies on Water-Catalyzed Mechanisms for Stereoinversion of Glutarimide Intermediates Formed from Glutamic Acid Residues in Aqueous Phase. Tomoki Nakayoshi, Shuichi Fukuyoshi, Koichi Kato, Eiji Kurimoto, Akifumi Oda. International journal of molecular sciences 20, 2410, 2019
Possible Mechanisms of Nonenzymatic Formation of Dehydroalanine Residue Catalyzed by Dihydrogen Phosphate Ion. Tomoki Nakayoshi, Koichi Kato, Eiji Kurimoto, Akifumi Oda. The journal of physical chemistry. B 123, 3147-3155, 2019Computational Studies on the Nonenzymatic Deamidation Mechanisms of Glutamine Residues. Koichi Kato, Tomoki Nakayoshi, Eiji Kurimoto, Akifumi Oda. ACS omega 4, 3508-3513, 2019
Computational studies on cyclic imide formation mechanism of glutamic acid residues catalyzed by two water molecules. T. Nakayoshi, K. Kato, S. Fukuyoshi, O. Takahashi, E. Kurimoto, A. Oda. Journal of Physics: Conference Series 1136, 12020, 2018
Prediction of the three-dimensional structures of histone deacetylase 1 complexed with romidepsin and FK-A5. A. Oda, K. Kato, M. Morino, T. Nakayoshi, S. Fukuyoshi, K. Saijo, C. Ishioka, E. Kurimoto. Journal of Physics: Conference Series 1136, 12019, 2018
Effect of the Arg456His mutation on the three-dimensional structure of cytochrome P450 1A2 predicted by molecular dynamics simulations. Y. Watanabe, K. Kato, S. Fukuyoshi, M. Hiratsuka, N. Yamaotsu, S. Hirono, H. Gouda, A. Oda. Journal of Physics: Conference Series 1136, 12023, 2018
Structural differences between the ligand-binding pockets of estrogen receptors alpha and beta. K. Kato, K. Fujii, T. Nakayoshi, Y. Watanabe, S. Fukuyoshi, K. Ohta, Y. Endo, N. Yamaotsu, S. Hirono, E. Kurimoto, A. Oda. Journal of Physics: Conference Series 1136, 12021, 2018
Comparison of the activation energy barrier for succinimide formation from α- and β-aspartic acid residues obtained from density functional theory calculations. Tomoki Nakayoshi, Koichi Kato, Shuichi Fukuyoshi, Ohgi Takahashi, Eiji Kurimoto, Akifumi Oda. Biochimica et biophysica acta. Proteins and proteomics 1866, 759-766, 2018
The assembly mechanism of coiled-coil domains of the yeast cargo receptors Emp46p/47p and the mutational alteration of pH-dependency of complex formation. Koichi Kato, Takahisa Furuhashi, Akifumi Oda, Eiji Kurimoto. Journal of Biochemistry 163, 441-446, 2018
Computational studies on the water-catalyzed stereoinversion mechanism of glutamic acid residues in peptides and proteins. Nakayoshi Tomoki, Kato Koichi, Fukuyoshi Shuichi, Takahashi Ohgi, Kurimoto Eiji, Akifumi Oda. Chirality 30, 527-535, 2018Validation of Molecular Dynamics Simulations for Prediction of Three-Dimensional Structures of Small Proteins. Koichi Kato, Tomoki Nakayoshi, Shuichi Fukuyoshi, Eiji Kurimoto, Akifumi Oda. Molecules 22, 1716, 2017
Investigation of substrate recognition for cytochrome P450 1A2 mediated by water molecules using docking and molecular dynamics simulations. Yurie Watanabe, Shuichi Fukuyoshi, Koichi Kato, Masahiro Hiratsuka, Noriyuki Yamaotsu, Shuichi Hirono, Hiroaki Gouda, Akifumi Oda. JOURNAL OF MOLECULAR GRAPHICS & MODELLING 74, 326-336, 2017