薬学部
教員紹介
![[写真]](/images/shared/teacher/pht_teacher517_s.jpg)
| 氏名 | 加藤 紘一 |
|---|---|
| フリガナ（ローマ字） | カトウ コウイチ（Koichi Kato） |
| 職名 | 講師 |
| 学位 | 博士（薬学） |
| 担当授業科目 | 分析化学Ⅱ,Ⅲ、分析化学実習、早期臨床体験実習、医療薬学チュートリアル演習Ⅰ,物理化学実習 |
| 専門分野 | 生物物理学、計算科学、タンパク質工学 |
| 現在の研究テーマ | タンパク質構造およびタンパク質間相互作用に関する研究、タンパク質の非酵素的翻訳後修飾に関する研究 |
| 研究内容キーワード | タンパク質間相互作用、非酵素的翻訳後修飾、分子動力学シミュレーション、量子化学計算、タンパク質工学 |
| ティーチング・ ポートフォリオ |
|
| 主な著書・学術論文 | Artificial helix supramolecule by doubly p-xylyl bridged bis(ZnII–cyclen) (cyclen = 1,4,7,10-tetraazacyclododecane) . Inorganic Chemistry Communications, 153, 110782, 2023 |
| Identification of the Most Impactful Asparagine Residues for γSCrystallin Aggregation by Deamidation. Biochemistry, 62, 1679-1688, 2023 | |
| Structural Characterization of Zinc(Ⅱ)/Cobalt(Ⅱ) Complexes of Chiral N-(Anthracen-9-yl)methyl-N,N-bis(2-picolyl)amine and Evaluation of DNA Photocleavage Activity. Chemical and Pharmaceutical Bulletin. 71, 545-551, 2023 | |
| Three-dimensional structure prediction of [GADS]-proteins as tentative primitive proteins.Chemistry Letters, 53,upae018, 2024 | |
| Structural Impact Assessment of Cytochrome P450 2A13 Polymorphisms Using Molecular Dynamics Simulations. Biological & pharmaceutical bulletin, 47, 620-628, 2024 | |
| Effect of the Addition of the Fifth Amino Acid to [GADV]-Protein on the Three-Dimensional Structure. Koichi Kato, Tomoki Nakayoshi, Ryota Oyaizu, Natsuko Noda, Eiji Kurimoto, Akifumi Oda. Life, 13, 246, 2023 | |
| Characterization of Zinc(II) Complex of 1,4,7,10-Tetrazacyclododecane and Deprotonated 5-Fluorouracil (FU) in Crystalline/Solution States and Evaluation of Anticancer Activity: Approach for Improving the Anticancer Activity of FU. Yoshimi Ichimaru, Koichi Kato, Rina Nakatani, Kirara Sugiura, Hideki Mizutani, Emiko Kinoshita-Kikuta, Tohru Koike, Wanchun Jin, Masanori Imai, Hiromasa Kurosaki. Inorganic Chemistry Communications, 147, 110221, 2023 | |
| Difference in the Inhibitory Effect of Thiol Compounds and Demetallation Rates from the Zn(II) Active Site of Metallo-β-lactamases (IMP-1 and IMP-6) Associated with a Single Amino Acid Substitution. Yoshihiro Yamaguchi, Koichi Kato, Yoshimi Ichimaru, Yuya Uenosono, Sakiko Tawara, Rio Ito, Natsuki Matsuse, Jun-ichi Wachino, Sachiko Toma-Fukai, Wanchun Jin, Yoshichika Arakawa, Masami Otsuka, Mikako Fujita, Nobuyuki Fukuishi, Kirara Sugiura, Masanori Imai, Hiromasa Kurosaki. ACS Infectious Diseases, 9, 65-78, 2022 | |
| Structural investigation of pathogenic variants in dihydropyrimidinase using molecular dynamics simulations. Koichi Kato, Tomoki Nakayoshi, Ayuka Nagura, Eiji Hishinuma, Masahira Hiratsuka, Eiji Kurimoto, Akifumi Oda. Journal of Molecular Graphics and Modelling, 117, 108288, 2022 | |
| Potential Anti-allergic Effects of Bibenzyl Derivatives from Liverworts, Radula perrottetii. Haruka Asai, Koichi Kato, Moe Suzuki, Mirei Takahashi, Erika Miyata, Moeka Aoi, Reika Kumazawa, Fuminori Nagashima, Hiromasa Kurosaki, Yutaka Aoyagi, Nobuyuki Fukuishi. Planta Medica, 88, 1069-1077, 2022 | |
| Bis(nitrato-κO)(1,4,8,11-tetraazacyclotetradecane-κ4N)zinc(II)methanol monosolvate. Yoshimi Ichimaru, Koichi Kato, Masaaki,Kurihara, Wanchun Jin, Toru Koike, Hiromasa Kurosaki. IUCrData, 7, x220854, 2022 | |
| Crystal Structure of [{m,m-bis(ZnII-cyclen)}3(μ2-CO3)2(H2O)2](ClO4)8·nH2O. Yoshimi Ichimaru, Koichi Kato, Kirara Sugiura, Chisa Hirata, Wanchun Jin, Haruto Fujioka, Hiromasa Kurosaki, Toru Koike. Computational and Theoretical Chemistry, 1209, 113605, 2022 | |
| Computational quantitation of the aldehyde forms of aldohexoses and disaccharides composed of d-glucose: Predictions of their reactivities in the Maillard reaction Koichi Kato, Yasuro Shinohara, Tomoki Nakayoshi, Eiji Kurimoto, Akifumi Oda, Yoshinobu Ishikawa Computational and Theoretical Chemistry, 1209. 113605-113605, 2022 |
|
| Nonenzymatic Deamidation Mechanism on a Glutamine Residue with a C-Terminal Adjacent Glycine Residue: A Computational Mechanistic Study. Haruka Asai, Koichi Kato, Tomoki Nakayoshi, Yoshinobu Ishikawa, Eiji Kurimoto, Akifumi Oda, Nobuyuki Fukuishi. AppliedChem, 1, 142-155, 2021 |
|
| Computational Analysis of the Mechanism of Nonenzymatic Peptide Bond Cleavage at the C-Terminal Side of an Asparagine Residue. Koichi Kato, Tomoki Nakayoshi, Yoshinobu Ishikawa, Eiji Kurimoto, Akifumi Oda. ACS omega 6, 30078-30084, 2021 | |
| Characterization of the Binding of Adenosine-5′-monophosphate to a µ-Type Alkoxide-Linked Dinuclear Zinc(II) Complex in Crystal and Solution State. Emiko Kinoshita-Kikuta,Yoshimi Ichimaru ,Yoshi Yamano,Koichi Kato,Hiromasa Kurosaki ,Eiji Kinoshita, and Tohru Koike. Bulletin of the Chemical Society of Japan, 11, 2011 | |
| Molecular dynamics simulations for the protein–ligand complex structures obtained by computational docking studies using implicit or explicit solvents. Koichi Kato, Tomoki Nakayoshi, Eiji Kurimoto, Akifumi Oda Chemical Physics Letters, 781, 139022, |
|
| Virtual Alanine Scan of the Main Protease Active Site in Severe Acute Respiratory Syndrome Coronavirus 2. Tomoki Nakayoshi, Koichi Kato, Eiji Kurimoto, Akifumi Oda. International journal of molecular sciences, 22, 9837, 2021 | |
| Deciphering Structural Alterations Associated with Activity Reductions of Genetic Polymorphisms in Cytochrome P450 2A6 Using Molecular Dynamics Simulations. Koichi Kato, Tomoki Nakayoshi, Rika Nokura, Hiroki Hosono, Masahiro Hiratsuka, Yoshinobu Ishikawa, Eiji Kurimoto, Akifumi Oda International journal of molecular sciences, 22, 10119, 2021 | |
| Crystal Structure of 2-(1-Benzoylazetidin-3-yl)thio-1,3-thiazoline. Kirara SUGIURA, Yoshimi Ichimaru, Koichi Kato, Masanori Imai, Hiromasa Kurosaki, Kazuhiko Hayashi. X-Ray Structure Analysis Online, 37, 2021 | |
| Crystal Structures of Metallo-β-Lactamase (IMP-1) and Its D120E Mutant in Complexes with Citrate and the Inhibitory Effect of the Benzyl Group in Citrate Monobenzyl Ester. Yoshihiro Yamaguchi, Koichi Kato, Yoshimi Ichimaru, Wanchun Jin, Misa Sakai, Miki Abe, Jun-ichi Wachino, Yoshichika Arakawa, Yukina Miyagi, Masanori Imai, Nobuyuki Fukuishi, Yuriko Yamagata, Masami Otsuka, Mikako Fujita, Hiromasa Kurosaki. Journal of Medicinal Chemistry 65, 10019-10026, 2021 | |
| Theoretical studies on the effect of isomerized aspartic acid residues on the three-dimensional structures of bovine pancreatic ribonucleases A. Tomoki Nakayoshi, Koichi Kato, Eiji Kurimoto, Akifumi Oda. Biological & pharmaceutical bulletin. 44, 967-975, 2021 | |
| Aqua(1,4,7,10-tetraazacyclododecane)zinc(II)bis(perchlorate) Yoshimi Ichimaru, Koichi Kato, Hiromasa Kurosaki, Haruto Fujioka, Misa Sakai, Yoshihiro Yamaguchi, Jin Wanchun, Kirara Sugiura, Masanori Imaia, Tohru Koike. IUCrData 6, x2103997, 2021 | |
| DNA-cleavage activity of the iron(II) complex with optically active ligands, meta- and para-xylyl-linked N',N'-dipyridylmethyl-cyclohexane-1,2-diamine. Koichi Kato,Yoshimi Ichimaru,Yoshinori Okuno,Yoshihiro Yamaguchi,Wanchun Jin,Mikako Fujita,Masami Otsuka,Masanori Imai,Hiromasa Kurosaki. Bioorganic & medicinal chemistry letters 36, 127834-127834, 2021 | |
| Modification of the pH Dependence of Assembly of Yeast Cargo Receptor Emp47p Coiled-Coil Domains: Computational Design and Experimental Mutagenesis. Koichi Kato,Tomoki Nakayoshi, Eiji Kurimoto, Akifumi Oda. The journal of physical chemistry. B 125, 2222-2230, 2021 | |
| Design and synthesis of an anthranyl bridged optically active dinuclear iron(II)-ligand and evaluation of DNA-cleaving activity. Yoshimi Ichimaru, Koichi Kato, Yoshinori Okuno, Yoshihiro Yamaguchi, Wanchun Jin, Mikako Fujita, Masami Otsuka, Masanori Imai, Hiromasa Kurosaki. Bioorganic & medicinal chemistry letters 35, 127782-127782, 2021 | |
| Molecular Mechanisms of Succinimide Formation from Aspartic Acid Residues Catalyzed by Two Water Molecules in the Aqueous Phase. Tomoki Nakayoshi, Koichi Kato, Shuichi Fukuyoshi, Ohgi Takahashi, Eiji Kurimoto, Akifumi Oda. International journal of molecular sciences. 22, 509, 2021 | |
| Crystal Structure of [11,14,17,110,51,54,57,510-Octaaza-1,5(1,4)-dicyclododecana-3,7(1,3)-dibenzenacyclooctaphane]zinc(II) tetrakis(nitrate), [m,m-bis(ZnII-cyclen)](NO3)4 Yoshimi Ichimaru, Wanchun Jin, Yoshihiro Yamaguchi, Kirara Sugiura, Masanori Imai, Hiromasa Kurosaki, Haruto Fujioka, Tohru Koike, Yuhzo Hieda, Koichi Kato. X-ray Structure Analysis Online 37, 15-16, 2020 | |
| Influence of the conformations of αA-crystallin peptides on the isomerization rates of aspartic acid residues. Tomoki Nakayoshi, Koichi Kato, Eiji Kurimoto, Akifumi Oda. Biochimica et biophysica acta. Proteins and proteomics 1868, 140480-140480, 2020 | |
| Mechanisms of Deamidation of Asparagine Residues and Effects of Main-Chain Conformation on Activation Energy. Koichi Kato, Tomoki Nakayoshi, Eiji Kurimoto, Akifumi Oda. International journal of molecular sciences 21, 7035, 2020 | |
| Computational studies on nonenzymatic succinimide-formation mechanisms of the aspartic acid residues catalyzed by two water molecules. Tomoki Nakayoshi, Koichi Kato, Shuichi Fukuyoshi, Hiro Takahashi, Ohgi Takahashi, Eiji Kurimoto, Akifumi Oda. Biochimica et biophysica acta. Proteins and proteomics 1868, 140459-140459, 2020 | |
| Analysis of the susceptibility of reducing disaccharides composed of d-glucose to glycation using the Maillard reaction and a novel sensitive method that measures the percentage of the open-ring form. Yasuro Shinohara, Yurika Ozawa, Akimi Okita, Koichi Kato, Taku Chiba, Nobuaki Miura, Jun-Ichi Furukawa. Carbohydrate research 493, 108019, 2020 | |
| Molecular Dynamics Simulations for Three-Dimensional Structures of Orotate Phosphoribosyltransferases Constructed from a Simplified Amino Acid Set. Koichi Kato, Tomoki Nakayoshi, Mizuha Sato, Eiji Kurimoto, Akifumi Oda. ACS omega 5, 13069-13076, 2020 | |
| Computational Studies on the Mechanisms of Nonenzymatic Intramolecular Cyclization of the Glutamine Residues Located at N-Termini Catalyzed by Inorganic Phosphate Species. Tomoki Nakayoshi, Koichi Kato, Eiji Kurimoto, Akifumi Oda. ACS omega 5, 9162-9170, 2020 | |
| Development of Force Field Parameters for p-Carborane to Investigate the Structural Influence of Carborane Derivatives on Drug Targets by Complex Formation. Koichi Kato, Tomoki Nakayoshi, Hiroki Inoue, Shuichi Fukuyoshi, Kiminori Ohta, Yasuyuki Endo, Eiji Kurimoto, Akifumi Oda. Biological & pharmaceutical bulletin 43, 1931-1939, 2020 | |
| Activation of Ligand Reaction on an Iron Complex: H/D Exchange Reaction of a Low-Spin Bis[2-(Pyridylmethylidene)-1-(2-pyridyl)methylamine]iron(II) Complex. Masanori Imai, Koichi Kato, Yoshihiro Yamaguchi, Mikako Fujita, Masami Otsuka, Hiromasa Kurosaki. Chemical & pharmaceutical bulletin 68, 713-716, 2020 | |
| Crystal Structure of [3-(1,4,7,10-Tetraazacyclododecan-1-yl)propan-1-amine]zinc(II) Bis(perchlorate), [ZnIL](ClO4)2. ICHIMARU Yoshimi, IMAI Masanori, FUJIOKA Haruto, HIEDA Yuhzo, KOIKE Tohru, KUROSAKI Hiromasa, KATO Koichi. X-Ray Structure Analysis Online (Web) 36, 43-44, 2020 | |
| Crystal Structure of 5-Methoxyindirubin 3-Oxime. NAKAMURA Niina, ICHIMARU Yoshimi, ICHIMARU Yoshimi, KATO Koichi, SANO Makoto, KUROSAKI Hiromasa, HAYASHI Kazuhiko, MIYAIRI Shinichi. X-Ray Structure Analysis Online (Web) 36, 47-48, 2020 | |
| ER subtype selectivity of m-carborane-containing phenols: C-alkyl groups on the m-carborane cage enhance ERα selectivity. Kiminori Ohta, Takumi Ogawa, Koichi Kato, Akifumi Oda, Yasuyuki Endo. Bioorganic & medicinal chemistry letters 29, 2290-2293, 2019 | |
| Three dimensional structures of putative, primitive proteins to investigate the origin of homochirality. Akifumi Oda, Tomoki Nakayoshi, Koichi Kato, Shuichi Fukuyoshi, Eiji Kurimoto. Scientific reports 9, 11594, 2019 | |
| Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues. Yukihiro Yoshida, Hidetsugu Fujigaki, Koichi Kato, Kyoka Yamazaki, Suwako Fujigaki, Kazuo Kunisawa, Yasuko Yamamoto, Akihiro Mouri, Akifumi Oda, Toshitaka Nabeshima, Kuniaki Saito. Scientific reports 9, 10243, 2019 | |
| Computational Studies on Water-Catalyzed Mechanisms for Stereoinversion of Glutarimide Intermediates Formed from Glutamic Acid Residues in Aqueous Phase. Tomoki Nakayoshi, Shuichi Fukuyoshi, Koichi Kato, Eiji Kurimoto, Akifumi Oda. International journal of molecular sciences 20, 2410, 2019 | |
| Possible Mechanisms of Nonenzymatic Formation of Dehydroalanine Residue Catalyzed by Dihydrogen Phosphate Ion. Tomoki Nakayoshi, Koichi Kato, Eiji Kurimoto, Akifumi Oda. The journal of physical chemistry. B 123, 3147-3155, 2019 | |
| Computational Studies on the Nonenzymatic Deamidation Mechanisms of Glutamine Residues. Koichi Kato, Tomoki Nakayoshi, Eiji Kurimoto, Akifumi Oda. ACS omega 4, 3508-3513, 2019 | |
| Computational studies on cyclic imide formation mechanism of glutamic acid residues catalyzed by two water molecules. T. Nakayoshi, K. Kato, S. Fukuyoshi, O. Takahashi, E. Kurimoto, A. Oda. Journal of Physics: Conference Series 1136, 12020, 2018 | |
| Prediction of the three-dimensional structures of histone deacetylase 1 complexed with romidepsin and FK-A5. A. Oda, K. Kato, M. Morino, T. Nakayoshi, S. Fukuyoshi, K. Saijo, C. Ishioka, E. Kurimoto. Journal of Physics: Conference Series 1136, 12019, 2018 | |
| Effect of the Arg456His mutation on the three-dimensional structure of cytochrome P450 1A2 predicted by molecular dynamics simulations. Y. Watanabe, K. Kato, S. Fukuyoshi, M. Hiratsuka, N. Yamaotsu, S. Hirono, H. Gouda, A. Oda. Journal of Physics: Conference Series 1136, 12023, 2018 | |
| Structural differences between the ligand-binding pockets of estrogen receptors alpha and beta. K. Kato, K. Fujii, T. Nakayoshi, Y. Watanabe, S. Fukuyoshi, K. Ohta, Y. Endo, N. Yamaotsu, S. Hirono, E. Kurimoto, A. Oda. Journal of Physics: Conference Series 1136, 12021, 2018 | |
| Comparison of the activation energy barrier for succinimide formation from α- and β-aspartic acid residues obtained from density functional theory calculations. Tomoki Nakayoshi, Koichi Kato, Shuichi Fukuyoshi, Ohgi Takahashi, Eiji Kurimoto, Akifumi Oda. Biochimica et biophysica acta. Proteins and proteomics 1866, 759-766, 2018 | |
| The assembly mechanism of coiled-coil domains of the yeast cargo receptors Emp46p/47p and the mutational alteration of pH-dependency of complex formation. Koichi Kato, Takahisa Furuhashi, Akifumi Oda, Eiji Kurimoto. Journal of Biochemistry 163, 441-446, 2018 | |
| Computational studies on the water-catalyzed stereoinversion mechanism of glutamic acid residues in peptides and proteins. Nakayoshi Tomoki, Kato Koichi, Fukuyoshi Shuichi, Takahashi Ohgi, Kurimoto Eiji, Akifumi Oda. Chirality 30, 527-535, 2018 | |
| Validation of Molecular Dynamics Simulations for Prediction of Three-Dimensional Structures of Small Proteins. Koichi Kato, Tomoki Nakayoshi, Shuichi Fukuyoshi, Eiji Kurimoto, Akifumi Oda. Molecules 22, 1716, 2017 | |
| Investigation of substrate recognition for cytochrome P450 1A2 mediated by water molecules using docking and molecular dynamics simulations. Yurie Watanabe, Shuichi Fukuyoshi, Koichi Kato, Masahiro Hiratsuka, Noriyuki Yamaotsu, Shuichi Hirono, Hiroaki Gouda, Akifumi Oda. JOURNAL OF MOLECULAR GRAPHICS & MODELLING 74, 326-336, 2017 |