薬学部
教員紹介
氏名 | 江川 大地 |
---|---|
フリガナ(ローマ字) | エガワ ダイチ(Daichi Egawa) |
職名 | 助教 |
学位 | 博士 (薬学) |
担当授業科目 | 天然薬物学実習、チーム医療論、生物学 |
専門分野 | 構造生物学、分子生物学 |
現在の研究テーマ | 天然由来生理活性分子の探索 |
研究内容キーワード | 生薬、漢方薬、CYP、核内受容体 |
ティーチング・ ポートフォリオ |
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主な著書・学術論文 | Egawa, D.; Ogiso, T.; Nishikata, K.; Yamamoto, K.; Itoh, T. Structural Insights into the Loss-of-Function R288H Mutant of Human PPARγ. Biol. Pharm. Bull. 2021, 44 (9), 1196–1201. |
Nakao, N.; Ueno, M.; Sakai, S.; Egawa, D.; Hanzawa, H.; Kawasaki, S.; Kumagai, K.; Suzuki, M.; Kobayashi, S.; Hanada, K. Natural Ligand-Nonmimetic Inhibitors of the Lipid-Transfer Protein CERT. Commun. Chem. 2019, 2 (1), 20. | |
Sugiki, T.; Egawa, D.; Kumagai, K.; Kojima, C.; Fujiwara, T.; Takeuchi, K.; Shimada, I.; Hanada, K.; Takahashi, H. Phosphoinositide Binding by the PH Domain in Ceramide Transfer Protein (CERT) Is Inhibited by Hyperphosphorylation of an Adjacent Serine-Repeat Motif. J. Biol. Chem. 2018, 293 (28), 11206–11217. | |
Egawa, D.; Itoh, T.; Kato, A.; Kataoka, S.; Anami, Y.; Yamamoto, K. SRC2-3 Binds to Vitamin D Receptor with High Sensitivity and Strong Affinity. Bioorg. Med. Chem. 2017, 25 (2), 568–574. | |
Kato, A.; Itoh, T.; Anami, Y.; Egawa, D.; Yamamoto, K. Helix12-Stabilization Antagonist of Vitamin D Receptor. Bioconjug. Chem. 2016, 27 (7), 1750–1761. | |
Anami, Y.; Shimizu, N.; Ekimoto, T.; Egawa, D.; Itoh, T.; Ikeguchi, M.; Yamamoto, K. Apo- and Antagonist-Binding Structures of Vitamin D Receptor Ligand-Binding Domain Revealed by Hybrid Approach Combining Small-Angle X-Ray Scattering and Molecular Dynamics. J. Med. Chem. 2016, 59 (17), 7888–7900. | |
Egawa, D.; Itoh, T.; Akiyama, Y.; Saito, T.; Yamamoto, K. 17-OxoDHA Is a PPARα/γ Dual Covalent Modifier and Agonist. ACS Chem. Biol. 2016, 11 (9), 2447–2455. | |
Egawa, D.; Itoh, T.; Yamamoto, K. Characterization of Covalent Bond Formation between PPARγ and Oxo-Fatty Acids. Bioconjug. Chem. 2015, 26 (4), 690–698. | |
Anami, Y.; Itoh, T.; Egawa, D.; Yoshimoto, N.; Yamamoto, K. A Mixed Population of Antagonist and Agonist Binding Conformers in a Single Crystal Explains Partial Agonism against Vitamin D Receptor: Active Vitamin D Analogues with 22 R -Alkyl Group. J. Med. Chem. 2014, 57 (10), 4351–4367. |