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学部・学科・専攻

教員紹介(薬学部 医療薬学科)

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2021年はコロナウイルスに振り回された一年でした。そんな中、コロナとの闘いに奮闘する医師や看護師達の影に隠れがちではありますが、ワクチンの管理や調製、感染された患者さんの治療に用いる薬の投与計画の立案等、チーム医療の“科学者”として、薬剤師もまた奮闘しています。今後登場するであろう新たな予防・治療戦略には、薬剤師の存在が必要不可欠です。みなさんも湘南医療大学で未来の薬剤師を目指しませんか?

氏名 山崎泰広
フリガナ(ローマ字) Yamazaki Yasuhiro
職名 准教授
学位 博士(薬学)
担当授業科目 生理学、生理解剖学実習、チーム医療論、早期臨床体験実習、後期臨床体験実習、医療薬学チュートリアル演習Ⅰ、薬局実務実習、薬学総合プレ研究、卒業研究Ⅰ、卒業研究Ⅱ、総合演習Ⅰ
専門分野 生化学、生理学、組織学
現在の研究テーマ 肝トランスポーター分子の機能異常が惹起する生活習慣病発症機構の解明
研究内容キーワード 生活習慣病、肝臓、トランスポーター
主な著書・学術論文

Sugatani, J., Noguchi, Y., Hattori, Y., Yamaguchi, M., Yamazaki, Y., Ikari, A.

Threonine-408 regulates the stability of human pregnane X receptor through its phosphorylation and the CHIP/Chaperone-Autophagy pathway.

Drug Metab. Dispos., 44, 137-150 (2016)

Yamazaki, Y., Yasui, K., Hashizume, T. et al.

Involvement of a cyclic adenosine monophosphate-dependent signal in the diet-induced canalicular trafficking of adenosine triphosphate-binding cassette transporter g5/g8.

Hepatology, 62, 1215-1226 (2015)

Yamaguchi, M., Matsui, M., Higa, R., Yamazaki, Y., et al

A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation.

Biochem. Pharmacol., 93, 482-495 (2014)

Sugatani, J., Hattori, Y., Noguchi, Y., Yamaguchi, M., Yamazaki, Y., Ikari, A.

Threonine-290 regulates nuclear translocation of the human pregnane X receptor through its phosphorylation/dephosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase I.

Drug Metab. Dispos., 42, 1708-1718 (2014)

Sugatani, J., Sadamitsu, S., Yamaguchi, M., Yamazaki, Y., et al.

Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age.

FASEB J., 28, 440-452 (2014)

Yamazaki, Y., Yasuda, K., Matuyama, T., et al

A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn -glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis)

Biochem Pharmacol., 86, 632-644 (2013)

Ikari, A., Atomi, K., Yamazaki, Y., et al.

Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation.

Biochim. Biophys. Acta., 1833, 2617-2627 (2013)

Osabe, M., Sugatani, J., Takemura, A., Yamazaki, Y., et al.

Effects of dietary inulin, statin, and their co-treatment on hyperlipidemia, hepatic steatosis and changes in drug-metabolizing enzymes in rats fed a high-fat and high-sucrose diet.

Nutr. Metab. (Lond.), 9, Article number 23 (2012)

Yamazaki, Y., Hashizume, T., Morioka, H., et al.

Diet-induced lipid accumulation in liver enhances ATP-binding cassette transporter g5/g8 expression at bile canaliculi.

Drug Metab. Pharmacokinet., 26, 442-450 (2011)

Kinoshita, M.O., Furuya, S., Ito, S., Shinoda, Y., Yamazaki, Y., et al.

Lipid rafts enriched in phosphatidylglucoside direct astroglial differentiation by regulating tyrosine kinase activity of epidermal growth factor receptors.

Biochem J., 419, 565-575 (2009)

Biochem J., 419, 565-575 (2009)

TComparison of enzymatically synthesized inulin, resistant maltodextrin and clofibrate effects on biomarkers of metabolic disease in rats fed a high-fat and high-sucrose (cafeteria) diet.

Eur J Nutr., 47, 192-200 (2008)

Yamazaki, Y., Horibata, Y., Nagatsuka, Y., et al.

Fucoganglioside α-fucosyl (α-galactosyl)-GM1: a novel member of lipid membrane microdomain components involved in PC12 cell neuritogenesis.

Biochem. J, 407, 31-40 (2007)

Nagatsuka, Y., Horibata, Y., Yamazaki, Y., et al.

Phosphatidylglucoside exists as a single molecular species with saturated fatty acyl chains in developing astroglial membranes.

Biochemistry, 45, 8742-8750 (2006)

Yamazaki, Y., Nagatsuka, Y., Oshima, E., et al.

Comprehensive analysis of monoclonal antibodies against detergent-insoluble membrane /lipid rafts of HL60 cells.

J Immunol. Methods., 311, 106-116 (2006)