薬学部
教員紹介
氏名 | 山崎 泰広 |
---|---|
フリガナ(ローマ字) | ヤマザキ ヤスヒロ(Yasuhiro Yamazaki) |
職名 | 准教授 |
学位 | 博士(薬学) |
担当授業科目 | 生理学、生理解剖学実習、チーム医療論、早期臨床体験実習、後期臨床体験実習、医療薬学チュートリアル演習Ⅰ、薬局実務実習、薬学総合プレ研究、卒業研究Ⅰ、卒業研究Ⅱ、総合演習Ⅰ |
専門分野 | 生化学、生理学、組織学 |
現在の研究テーマ | 肝トランスポーター分子の機能異常が惹起する生活習慣病発症機構の解明 |
研究内容キーワード | 生活習慣病、肝臓、トランスポーター |
ティーチング・ ポートフォリオ |
|
主な著書・学術論文 | Sugatani, J., Noguchi, Y., Hattori, Y., Yamaguchi, M., Yamazaki, Y., Ikari, A. Threonine-408 regulates the stability of human pregnane X receptor through its phosphorylation and the CHIP/Chaperone-Autophagy pathway. Drug Metab. Dispos., 44, 137-150 (2016) |
Yamazaki, Y., Yasui, K., Hashizume, T. et al. Involvement of a cyclic adenosine monophosphate-dependent signal in the diet-induced canalicular trafficking of adenosine triphosphate-binding cassette transporter g5/g8. Hepatology, 62, 1215-1226 (2015) |
|
Yamaguchi, M., Matsui, M., Higa, R., Yamazaki, Y., et al A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation. Biochem. Pharmacol., 93, 482-495 (2014) |
|
Sugatani, J., Hattori, Y., Noguchi, Y., Yamaguchi, M., Yamazaki, Y., Ikari, A. Threonine-290 regulates nuclear translocation of the human pregnane X receptor through its phosphorylation/dephosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase I. Drug Metab. Dispos., 42, 1708-1718 (2014) |
|
Sugatani, J., Sadamitsu, S., Yamaguchi, M., Yamazaki, Y., et al. Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age. FASEB J., 28, 440-452 (2014) |
|
Yamazaki, Y., Yasuda, K., Matuyama, T., et al A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn -glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) Biochem Pharmacol., 86, 632-644 (2013) |
|
Ikari, A., Atomi, K., Yamazaki, Y., et al. Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation. Biochim. Biophys. Acta., 1833, 2617-2627 (2013) |
|
Osabe, M., Sugatani, J., Takemura, A., Yamazaki, Y., et al. Effects of dietary inulin, statin, and their co-treatment on hyperlipidemia, hepatic steatosis and changes in drug-metabolizing enzymes in rats fed a high-fat and high-sucrose diet. Nutr. Metab. (Lond.), 9, Article number 23 (2012) |
|
Yamazaki, Y., Hashizume, T., Morioka, H., et al. Diet-induced lipid accumulation in liver enhances ATP-binding cassette transporter g5/g8 expression at bile canaliculi. Drug Metab. Pharmacokinet., 26, 442-450 (2011) |
|
Kinoshita, M.O., Furuya, S., Ito, S., Shinoda, Y., Yamazaki, Y., et al. Lipid rafts enriched in phosphatidylglucoside direct astroglial differentiation by regulating tyrosine kinase activity of epidermal growth factor receptors. Biochem J., 419, 565-575 (2009) |
|
Biochem J., 419, 565-575 (2009) TComparison of enzymatically synthesized inulin, resistant maltodextrin and clofibrate effects on biomarkers of metabolic disease in rats fed a high-fat and high-sucrose (cafeteria) diet. Eur J Nutr., 47, 192-200 (2008) |
|
Yamazaki, Y., Horibata, Y., Nagatsuka, Y., et al. Fucoganglioside α-fucosyl (α-galactosyl)-GM1: a novel member of lipid membrane microdomain components involved in PC12 cell neuritogenesis. Biochem. J, 407, 31-40 (2007) |
|
Nagatsuka, Y., Horibata, Y., Yamazaki, Y., et al. Phosphatidylglucoside exists as a single molecular species with saturated fatty acyl chains in developing astroglial membranes. Biochemistry, 45, 8742-8750 (2006) |
|
Yamazaki, Y., Nagatsuka, Y., Oshima, E., et al. Comprehensive analysis of monoclonal antibodies against detergent-insoluble membrane /lipid rafts of HL60 cells. J Immunol. Methods., 311, 106-116 (2006) |